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Bacteriophages in water pollution control: Advantages and limitations
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1378-y
•Phages can be better indicators of enteric viruses than fecal indicator bacteria.
关键词: Phage Water pollution monitoring Harmful bacteria biocontrol Horizontal gene transfer Bacterial resistance
Assessment of antibiotic resistance genes in dialysis water treatment processes
Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1136-1
• Quantitative global ARGs profile in dialysis water was investigated. • Totally 35 ARGs were found in the dialysis treatment train. • 29 ARGs (highest) were found in carbon filtration effluent. • erm and mtrD-02 occurred in the final effluent. • The effluent was associated with health risks even after RO treatment.
关键词: Dialysis water Treatment process Antibiotic resistance gene High-throughput quantitative PCR Horizontal gene transfer
Natural convection heat transfer of water in a horizontal circular gap
SU Guanghui, WU Yingwei, Kenichiro Sugiyama
《能源前沿(英文)》 2007年 第1卷 第2期 页码 167-173 doi: 10.1007/s11708-007-0021-y
关键词: function diameter different independent different characteristic horizontal downward
Convective mass transfer from a horizontal rotating cylinder in a slot air jet flow
Hongting MA , Dandan MA , Na YANG ,
《能源前沿(英文)》 2009年 第3卷 第3期 页码 289-296 doi: 10.1007/s11708-009-0019-8
关键词: air jet impinging rotating cylinder critical point mass transfer characteristics
LV Jing, FU Meng, QIN Na, DONG Bin
《能源前沿(英文)》 2008年 第2卷 第3期 页码 339-343 doi: 10.1007/s11708-008-0045-y
关键词: conventional experimental condition vertical Reynolds number transfer
Qingkun Ji, Caihong Zhang, Dan Li
《环境科学与工程前沿(英文)》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1287-0
关键词: Nanofullerene Sub-minimum inhibitory concentrations Antibiotic resistance genes Conjugation Molecular biological techniques
Xin ZOU, Maoqiong GONG, Gaofei CHEN, Zhaohu SUN, Jianfeng WU
《能源前沿(英文)》 2010年 第4卷 第4期 页码 527-534 doi: 10.1007/s11708-010-0109-7
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
《医学前沿(英文)》 2009年 第3卷 第2期 页码 141-147 doi: 10.1007/s11684-009-0041-6
Virender K. Sharma, Xin Yu, Thomas J. McDonald, Chetan Jinadatha, Dionysios D. Dionysiou, Mingbao Feng
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1122-7
Antibiotic-resistant bacteria and antibiotic resistance genes are in water bodies. UV/chlorination method is better to remove ARGs than UV or chlorination alone. Research on UV/hydrogen peroxide to eliminate ARGs is forthcoming. UV-based photocatalytic processes are effective to degrade ARGs.
关键词: Antibiotic resistance bacteria Advanced oxidation processes Disinfection Reactive chlorine species Sulfate radicals Reactive oxygen species
Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 90-99 doi: 10.1007/s11684-015-0390-2
Gene therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed gene transfer mediated by adeno-associated viral vectors. Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-human codon-optimized factor IX (AAV8-hFIXco) vector demonstrated encouraging efficacy with hFIX expression stabilized at 1% to 6% of normal level in patients, but safety concerns related to high vector doses are still present. Thus, further improvement of AAV vectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B gene therapy. In this study, to obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human FIX expression vector was optimized by upgrading the codon adaption index and adjusting the GC content, inserting a Kozak sequence (GCCACC), and introducing a gain-of-function mutation, R338L (FIX Padua). The efficiency of the published and the presently constructed cassettes was compared through in vivo screening. In addition, the regulatory elements that control the FIX gene expression in these cassettes were screened for liver-specific effectiveness. Among all the constructed cassettes, scAAV-Pre-hFIXco-SIH-R338L, which was the construct under the control of the prothrombin enhancer and prealbumin promoter, resulted in the highest level of coagulant activity, and the expression levels of two constructed cassettes (scAAV-Chi-hFIXco-SIH-R338L and scAAV-Pre-hFIXco-SIH-R338L) were also higher than that of the published cassette (scAAV-LP1-hFIXco-SJ). In summary, our strategies led to a substantial increase in hFIX expression at the protein level or a remarkably elevated coagulant activity. Thus, these reconstructs of hFIX with AAV vector may potentially contribute to the creation of an efficacious gene therapy of hemophilia B.
关键词: factor IX hemophilia B liver-specific regulatory elements hydrodynamic gene transfer
Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 87-96 doi: 10.15302/J-FASE-2016087
关键词: safety of transgenic bicistron gene transfer body transgenic mice muscle development
Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers
Ulrich L?CHELT, Ernst WAGNER
《化学科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 275-286 doi: 10.1007/s11705-011-1203-z
Numerical simulation of liquid falling film on horizontal circular tubes
Fengdan SUN, Songlin XU, Yongchuan GAO
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 322-328 doi: 10.1007/s11705-012-1296-z
关键词: falling film horizontal tube flow characteristics film thickness liquid feeder height
《结构与土木工程前沿(英文)》 2023年 第17卷 第2期 页码 224-237 doi: 10.1007/s11709-022-0914-1
关键词: single batter pile skew horizontal load model test finite-element analysis empirical design method
Experimental study on shear behavior of reinforced concrete beams with web horizontal reinforcement
Dong XU,Yu ZHAO,Chao LIU
《结构与土木工程前沿(英文)》 2014年 第8卷 第4期 页码 325-336 doi: 10.1007/s11709-014-0080-1
关键词: reinforced concrete beam shear strength web horizontal reinforcement experiments
标题 作者 时间 类型 操作
Assessment of antibiotic resistance genes in dialysis water treatment processes
Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng
期刊论文
Natural convection heat transfer of water in a horizontal circular gap
SU Guanghui, WU Yingwei, Kenichiro Sugiyama
期刊论文
Convective mass transfer from a horizontal rotating cylinder in a slot air jet flow
Hongting MA , Dandan MA , Na YANG ,
期刊论文
Experimental study on heat transfer characteristics of supercritical carbon dioxide in horizontal tube
LV Jing, FU Meng, QIN Na, DONG Bin
期刊论文
Influences and mechanisms of nanofullerene on the horizontal transfer of plasmid-encoded antibiotic resistance
Qingkun Ji, Caihong Zhang, Dan Li
期刊论文
Experimental study on saturated flow boiling heat transfer of R290/R152a binary mixtures in a horizontal
Xin ZOU, Maoqiong GONG, Gaofei CHEN, Zhaohu SUN, Jianfeng WU
期刊论文
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
期刊论文
Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment
Virender K. Sharma, Xin Yu, Thomas J. McDonald, Chetan Jinadatha, Dionysios D. Dionysiou, Mingbao Feng
期刊论文
Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B
null
期刊论文
Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions
Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI
期刊论文
Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers
Ulrich L?CHELT, Ernst WAGNER
期刊论文
Numerical simulation of liquid falling film on horizontal circular tubes
Fengdan SUN, Songlin XU, Yongchuan GAO
期刊论文
Numerical analysis of bearing behaviors of single batter piles under horizontal loads in various directions
期刊论文